Purine nucleosides

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Purine nucleosides are antiviral agents that have selective activity against herpes simplex virus types 1 (cold sores) and 2 (genital herpes) and varicella zoster virus (chicken pox).

The purine nucleoside molecule is converted to a monophosphate by viral thymidine kinases. The monophosphate is then converted to diphosphate and then into a triphosphate form by cellular enzymes. The triphosphate form blocks the replication of viral DNA by inhibiting viral DNA polymerase and terminating the growing viral DNA chain.

Purine nucleosides are more potent against the viral enzymes than the host enzymes.

See also

Medical conditions associated with purine nucleosides:

• CMV Retinitis
• Cold Sores
• Cytomegalovirus Infection
• Hepatitis C
• Herpes Simplex
• Herpes Simplex Encephalitis
• Herpes Simplex, Mucocutaneous/Immunocompetent Host
• Herpes Simplex, Mucocutaneous/Immunocompromised Host
• Herpes Simplex, Suppression
• Herpes Zoster
• Multiple Sclerosis
• Respiratory Syncytial Virus
• Smallpox Vaccine Reaction
• Varicella-Zoster

Drug List:

Valtrex

Zovirax

Famvir

Copegus

Ribapak

Cytovene

Rebetol

Ribasphere

Ribatab

Valcyte

Virazole-Solution

Vistide

aspirin/diphenhydramine/phenylpropanolamine

Generic Name: aspirin/diphenhydramine/phenylpropanolamine (AS pir in/dye fen HYE dra meen/fen ill proe pa NOLE a meen)

Brand names: Alka Seltzer Plus Night Time Effervescent, Alka-Seltzer Plus Night Time Effervescent

What is aspirin/diphenhydramine/phenylpropanolamine?

Aspirin is in a class of drugs called salicylates. Aspirin is a pain reliever, an anti-inflammatory, and a fever reducer. It is used to treat many conditions, such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.

Diphenhydramine is an antihistamine. It blocks the naturally occurring chemical histamine in the body. Diphenhydramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces blood flow to affected areas and allows nasal passages to open up.

The combination, aspirin/diphenhydramine/phenylpropanolamine, is used to treat nasal congestion, sinusitis (inflammation of the sinuses), headache, fever, and aches and pains associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Aspirin/diphenhydramine/phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about aspirin/diphenhydramine/phenylpropanolamine?

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Use caution when driving, operating machinery, or performing other hazardous activities. Aspirin/diphenhydramine/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking aspirin/diphenhydramine/phenylpropanolamine. Alcohol can be damaging to the stomach when it is taken with aspirin.

Do not take more of this medication than is directed. Consult your doctor if you symptoms are not being relieved.

Who should not take aspirin/diphenhydramine/phenylpropanolamine?

Do not take this medication without first talking to your doctor if you drink more than three alcoholic beverages per day. Alcohol can cause stomach bleeding when it is combined with any medicine that contains aspirin.

Do not take aspirin/diphenhydramine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• 
  

  an ulcer or a bleeding or coagulation disorder,

  
  


• kidney disease,


• liver disease,


• 
  

  diabetes,

  
  


• 
  

  glaucoma,

  
  


• 
  

  any type of heart disease or high blood pressure,

  
  


• 
  

  thyroid disease,

  
  


• 
  

  emphysema or chronic bronchitis, or

  
  


• 
  

  difficulty urinating or an enlarged prostate.

  
  

You may not be able to take aspirin/diphenhydramine/phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether aspirin/diphenhydramine/phenylpropanolamine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. This medication passes into breast milk and can harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from aspirin/diphenhydramine/phenylpropanolamine. You may require a lower dose of this medication. Do not use any medication that contains aspirin to treat a child or teenager who has a fever, flu symptoms, or chicken pox without first talking to a doctor. In children younger than 20 years of age, aspirin may increase the risk of Reye's syndrome, a rare but often fatal condition.

How should I take aspirin/diphenhydramine/phenylpropanolamine?

Take aspirin/diphenhydramine/phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse or doctor to explain them to you.

Take each dose with a full glass of water. Take this medication with food or milk if stomach upset occurs. Do not take more of this medication than is recommended.

Do not take aspirin/diphenhydramine/phenylpropanolamine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, see your doctor.

Store aspirin/diphenhydramine/phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an aspirin/diphenhydramine/phenylpropanolamine overdose include a dry mouth, large pupils, flushing, ringing in the ears, dizziness, hallucinations, seizures, rapid breathing, nausea, and vomiting.

What should I avoid while taking aspirin/diphenhydramine/phenylpropanolamine?

Use caution when driving, operating machinery, or performing other hazardous activities. Aspirin/diphenhydramine/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking aspirin/diphenhydramine/phenylpropanolamine. Also, alcohol can cause stomach bleeding when it is combined with any medicine that contains aspirin.

Aspirin/diphenhydramine/dextromethorphan/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if aspirin/diphenhydramine/phenylpropanolamine is taken with any of these medications.

Avoid prolonged exposure to sunlight. Aspirin/diphenhydramine/phenylpropanolamine may increase the sensitivity of the skin to sunlight. Use a sun screen and wear protective clothing when sun exposure is unavoidable.

Be aware of the aspirin content of other over-the-counter and prescription products. Any aspirin content in these products counts toward your total daily dose.

Aspirin/diphenhydramine/ phenylpropanolamine side effects

If you experience any of the following serious side effects, stop taking aspirin/diphenhydramine/phenylpropanolamine and seek emergency medical attention or notify your doctor immediately:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  
  


• 
  

  black, bloody, or tarry stools;

  
  


• 
  

  blood in vomit or urine;

  
  


• 
  

  nausea, vomiting, or abdominal pain;

  
  


• 
  

  uncontrolled fever;

  
  


• 
  

  seizures;

  
  


• 
  

  an irregular heartbeat; or

  
  


• 
  

  abnormal behavior, hallucinations, or paranoia.

  
  

Other, less serious side effects may be more likely to occur. Continue to take aspirin/diphenhydramine/phenylpropanolamine and talk to your doctor, or try another similar medication if you experience

• 
  

  dryness of the eyes, nose, and mouth;

  
  


• 
  

  drowsiness, lightheadedness, dizziness, or weakness;

  
  


• 
  

  headache;

  
  


• 
  

  faint ringing in the ears;

  
  


• 
  

  upset stomach or indigestion;

  
  


• 
  

  blurred vision;

  
  


• 
  

  restlessness, tremor, insomnia, or anxiety;

  
  


• 
  

  sweating;

  
  


• 
  

  difficulty urinating; or

  
  


• 
  

  excitation in children.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect aspirin/diphenhydramine/phenylpropanolamine?

Do not take aspirin/diphenhydramine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take other over-the-counter cough, cold, allergy, diet, fever, pain, or sleep aids while taking aspirin/diphenhydramine/phenylpropanolamine unless your pharmacist or doctor approves. Other medications may also contain aspirin, diphenhydramine, phenylpropanolamine, or other similar drugs, and you may accidentally take too much and harm yourself.

Aspirin/diphenhydramine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if aspirin/diphenhydramine/phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with aspirin/diphenhydramine/phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More aspirin/diphenhydramine/phenylpropanolamine resources

• Aspirin/diphenhydramine/phenylpropanolamine Drug Interactions
• Aspirin/diphenhydramine/phenylpropanolamine Support Group
• 0 Reviews · Be the first to review/rate this drug

Where can I get more information?

• Your pharmacist has additional information about aspirin/diphenhydramine/ phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

Aspirin/diphenhydramine/phenylpropanolamine is available over the counter under the brand name Night Time Effervescent Cold Tablets. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Metenix 5 Tablets

1. Name Of The Medicinal Product

Metenix 5mg Tablets

2. Qualitative And Quantitative Composition

Metolazone 5 mg

3. Pharmaceutical Form

Tablet

4. Clinical Particulars

4.1 Therapeutic Indications

Metenix 5mg Tablets is a diuretic for use in the treatment of mild and moderate hypertension. Metenix 5mg Tablets may be used in conjunction with non-diuretic antihypertensive agents and, in these circumstances, it is usually possible to achieve satisfactory control of blood pressure with a reduced dose of the non-diuretic agent. Patients who have become resistant to therapy with these agents may respond to the addition of Metenix 5mg Tablets to their antihypertensive regimen.

Metenix 5mg Tablets may also be used for the treatment of cardiac, renal and hepatic oedema, ascites or toxaemia of pregnancy.

4.2 Posology And Method Of Administration

Route of administration: Oral

Hypertension: The recommended initial dose in mild and moderate hypertension is 5 mg daily. After three to four weeks, the dose may be reduced if necessary to 5 mg on alternate days as maintenance therapy.

Oedema: In oedematous conditions, the normal recommended dose is 5-10 mg daily, given as a single dose. In resistant conditions, this may be increased to 20 mg daily or above. However, no more than 80 mg should be given in any 24-hour period.

Children: There is insufficient knowledge of the effects of Metenix 5mg Tablets in children for any dosage recommendations to be made.

Elderly: Metolazone may be excreted more slowly in the elderly.

4.3 Contraindications

Metenix 5mg Tablets is contra-indicated in electrolyte deficiency states, anuria, coma or pre-comatose states associated with liver cirrhosis; also in patients with known allergy or hypersensitivity to metolazone.

4.4 Special Warnings And Precautions For Use

Because of the antihypertensive effects of metolazone the dosage of concurrently administered non-diuretic antihypertensive agents may need to be reduced.

Caution should be exercised during Metenix 5mg Tablets therapy in patients liable to electrolyte deficiency.

Chloride deficit, hyponatraemia and a low salt syndrome may also occur, particularly when the patient is also on a diet with restricted salt intake. Hypomagnesaemia has been reported as a consequence of prolonged diuretic therapy.

Prolonged therapy with Metenix 5mg Tablets may result in hypokalaemia. Serum potassium levels should be determined at regular intervals and, if necessary, potassium supplementation should be instituted.

Fluid and electrolyte balance should be carefully monitored during therapy especially if Metenix 5mg Tablets is used concurrently with other diuretics. In particular, Metenix 5mg Tablets may potentiate the diuresis produced by furosemide and, if the two agents are used concurrently, patients should be carefully monitored.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

The dosage of concurrently administered cardiac glycosides may require adjustment. Metenix 5mg Tablets may aggravate the increased potassium excretion associated with steroid therapy or diseases such as cirrhosis or severe ischaemic heart disease. Latent diabetes may become manifest or the insulin requirements of diabetic patients may increase.

Non steroidal anti-inflammatory drugs (e.g. Indometacin, Sulindac) may attenuate the action of Metolazone.

Prolongation of bleeding time has been reported during concomitant administration of Metenix and warfarin.

4.6 Pregnancy And Lactation

There is little evidence of safety of the drug in human pregnancy, but it has been in wide, general use for many years without apparent ill consequence, animal studies having shown no hazard.

If Metenix 5mg Tablets is given to nursing mothers, metolazone may be present in the breast milk.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Metenix 5mg Tablets is generally well tolerated. There have been occasional reports of headache, anorexia, vomiting, abdominal discomfort, muscle cramps and dizziness. There have been isolated reports of urticaria, leucopenia, tachycardia, chills and chest pain.

Hyperuricaemia or azotaemia may occur during treatment with Metenix 5mg Tablets, particularly in patients with impaired renal function. On rare occasions, clinical gout has been reported.

4.9 Overdose

In cases of overdose there is a danger of dehydration and electrolyte depletion. Treatment should therefore be aimed at fluid replacement and correction of the electrolyte imbalance.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Metolazone is a substituted quinazolinone diuretic.

5.2 Pharmacokinetic Properties

Diuresis and saluresis begin within one hour of administration of Metenix 5mg Tablets tablets, reaching a maximum in two hours and continuing for 12-24 hours according to dosage.

5.3 Preclinical Safety Data

None applicable.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Microcrystalline cellulose, magnesium stearate, F D and C blue no 2 lake (E132)

6.2 Incompatibilities

None.

6.3 Shelf Life

5 years.

6.4 Special Precautions For Storage

Metenix 5mg Tablets tablets should be stored protected from light, in the original container or in containers similar to those of the manufacturer.

6.5 Nature And Contents Of Container

Blister pack of 100 tablets.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Sanofi-aventis

One Onslow Street

Guildford

Surrey, GU1 4YS, UK

8. Marketing Authorisation Number(S)

PL 04425/0212

9. Date Of First Authorisation/Renewal Of The Authorisation

5 November 2001

10. Date Of Revision Of The Text

21 September 2010

LEGAL STATUS

POM

Quinidex Extentabs

Generic Name: quinidine (Oral route, Injection route, Intramuscular route)

KWIN-i-deen

Oral route(Tablet, Extended Release)

Many trials of antiarrhythmic therapy for non-life threatening arrhythmias, has resulted in increased mortality; the risk of active therapy is probably greatest in patients with structural heart disease. In the case of quinidine used to prevent or defer recurrence of atrial flutter/fibrillation, meta-analysis data has shown that the mortality associated with the use of quinidine was more than three times greater than placebo. Another meta-analysis showed that in patients with various non-life-threatening ventricular arrhythmias, the mortality associated with the use of quinidine was consistently greater than that associated with the use of any of a variety of alternative antiarrhythmics .

Oral route(Tablet)

Many trials of antiarrhythmic therapy for non-life threatening arrhythmias, has resulted in increased mortality; the risk of active therapy is probably greatest in patients with structural heart disease. In the case of quinidine used to prevent or defer recurrence of atrial flutter/fibrillation, meta-analysis data has shown that the mortality associated with the use of quinidine was more than three times greater than placebo. Another meta-analysis showed that in patients with various non-life-threatening ventricular arrhythmias, the mortality associated with the use of quinidine was consistently greater than that associated with the use of any of a variety of alternative antiarrhythmics .

Commonly used brand name(s)

In the U.S.

• Cardioquin


• Quinaglute


• Quinalan


• Quinidex Extentabs

Available Dosage Forms:

• Tablet


• Tablet, Extended Release


• Capsule


• Solution

Therapeutic Class: Antiarrhythmic, Group IA

Chemical Class: Cinchona Alkaloid

Uses For Quinidex Extentabs

Quinidine is used to treat abnormal heart rhythms. It is also used to treat malaria.

Do not confuse this medicine with quinine, which, although related, has different medical uses.

Quinidine is available only with your doctor's prescription.

Before Using Quinidex Extentabs

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Quinidine has not been widely studied in children; however, it is used in children to treat abnormal heart rhythms and to treat malaria. Children may be able to take higher doses than adults and may have fewer side effects (such as vomiting, loss of appetite, and diarrhea) than adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of quinidine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. However, quinidine may remain in the bodies of older adults longer than it does in younger adults, which may increase the risk of side effects and which may require lower doses.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Aurothioglucose


• Bepridil


• Cisapride


• Dronedarone


• Grepafloxacin


• Itraconazole


• Levomethadyl


• Mesoridazine


• Nelfinavir


• Pimozide


• Posaconazole


• Ritonavir


• Saquinavir


• Sparfloxacin


• Terfenadine


• Thioridazine


• Tipranavir


• Voriconazole


• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetazolamide


• Ajmaline


• Alfuzosin


• Amiodarone


• Amitriptyline


• Amoxapine


• Amprenavir


• Apomorphine


• Aprindine


• Arbutamine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Atazanavir


• Atracurium


• Azithromycin


• Boceprevir


• Chloral Hydrate


• Chloroquine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Colchicine


• Crizotinib


• Darunavir


• Dasatinib


• Decamethonium


• Delavirdine


• Desipramine


• Digitoxin


• Digoxin


• Disopyramide


• Dofetilide


• Dolasetron


• Doxepin


• Droperidol


• Enflurane


• Erythromycin


• Etravirine


• Flecainide


• Fluconazole


• Fosamprenavir


• Foscarnet


• Gatifloxacin


• Gemifloxacin


• Granisetron


• Halofantrine


• Haloperidol


• Halothane


• Hydroquinidine


• Ibutilide


• Imipramine


• Infliximab


• Isoflurane


• Isradipine


• Lanreotide


• Lapatinib


• Levofloxacin


• Lidocaine


• Lidoflazine


• Lopinavir


• Lorcainide


• Lumefantrine


• Mefloquine


• Methadone


• Mexiletine


• Moxifloxacin


• Nalidixic Acid


• Nilotinib


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Paliperidone


• Pancuronium


• Pazopanib


• Pentamidine


• Perflutren Lipid Microsphere


• Pirmenol


• Prajmaline


• Prilocaine


• Probucol


• Procainamide


• Prochlorperazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Salmeterol


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Spiramycin


• Succinylcholine


• Sulfamethoxazole


• Sunitinib


• Telaprevir


• Telavancin


• Telithromycin


• Tetrabenazine


• Toremifene


• Trazodone


• Trifluoperazine


• Trimethoprim


• Trimipramine


• Tubocurarine


• Vandetanib


• Vardenafil


• Vasopressin


• Vecuronium


• Vemurafenib


• Zolmitriptan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abarelix


• Amiloride


• Aripiprazole


• Atenolol


• Cimetidine


• Clozapine


• Dalfopristin


• Dextromethorphan


• Dicumarol


• Fosphenytoin


• Galantamine


• Ketoconazole


• Magaldrate


• Magnesium Carbonate


• Magnesium Hydroxide


• Magnesium Oxide


• Magnesium Trisilicate


• Metoprolol


• Nifedipine


• Nisoldipine


• Paroxetine


• Phenobarbital


• Phenytoin


• Propranolol


• Quinupristin


• Rifapentine


• Timolol


• Tolterodine


• Tramadol


• Verapamil

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Electrolyte disorders—Quinidine may worsen heart rhythm problems

• Heart disease or


• Myasthenia gravis—Quinidine may make these conditions worse

• Kidney disease or


• Liver disease—Effects may be increased because of slower removal of quinidine from the body

Proper Use of quinidine

This section provides information on the proper use of a number of products that contain quinidine. It may not be specific to Quinidex Extentabs. Please read with care.

Take this medicine exactly as directed. Do not take more of this medicine and do not take it more often than your doctor ordered. Do not miss any doses.

Taking quinidine with food may help lessen stomach upset.

For patients taking the extended-release tablet form of this medicine:

• Quinidex Extentabs or Biquin Durules—Swallow the tablets whole; do not break, crush, or chew before swallowing. Note that Biquin Durules may sometimes appear as a whole tablet in the stool; this tablet is just the empty shell that is left after the medicine has been absorbed into the body.


• Quinaglute Duratabs or Quin-Release—These tablets may be broken in half; however, they should not be crushed or chewed before swallowing.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For regular (short-acting) oral dosage form (tablets):
  
  • For abnormal heart rhythm:
    
    • Adults—200 to 650 milligrams (mg) three or four times a day.
    
    
    • Children—30 to 40 mg per kilogram (kg) (13.6 to 18.2 mg per pound) of body weight per day. Your doctor may increase the dose if needed.
    
    
  
  


• For long-acting oral dosage form (tablets):
  
  • For abnormal heart rhythm:
    
    • Adults—300 to 660 mg every eight to twelve hours.
    
    
    • Children—30 to 40 mg per kilogram (kg) (13.6 to 18.2 mg per pound) of body weight per day. Your doctor may increase the dose if needed.
    
    
  
  


• For injection dosage form:
  
  • For abnormal heart rhythm:
    
    • Adults—190 to 380 mg injected into the muscle every two to four hours. Or, up to 0.25 mg per kg (0.11 mg per pound) of body weight per minute in a solution injected into a vein.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  
  • For malaria:
    
    • Adults—10 mg per kg (4.54 mg per pound) of body weight in a solution injected slowly into a vein over one to two hours. Then, 0.02 mg per kg (0.009 mg per pound) of body weight per minute is given. Or, 24 mg per kg (10.91 mg per pound) of body weight in a solution injected slowly into a vein over a four-hour period. Then, eight hours after the first dose, 12 mg per kg (5.45 mg per pound) of body weight, injected slowly into a vein over a four-hour period, and repeated every eight hours.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Quinidex Extentabs

It is very important that your doctor check your progress at regular visits to make sure that the quinidine is working properly and does not cause unwanted effects.

Do not stop taking this medicine without first checking with your doctor, to avoid possible worsening of your condition.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

Dizziness or lightheadedness may occur with this medicine, especially when you get up from a lying or sitting position. Getting up slowly may help.

Fainting may occur with this medicine. Do not drive or do anything else that could be dangerous if fainting occurs.

. Check with your doctor immediately if you faint or experience other side effects with this medicine.

Your doctor may want you to carry a medical identification card or bracelet stating that you are using this medicine.

Quinidex Extentabs Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Abdominal pain and/or yellow eyes or skin


• blurred and/or double vision, confusion, delirium, disturbed color perception, headache, noises or ringing in the ear, and/or visual intolerance of light


• dizziness or lightheadedness


• fainting


• fever

Rare

• Chest pain, fever, general discomfort, joint pain, joint swelling, muscle pain, and/or skin rash


• nosebleeds or bleeding gums


• unusual tiredness or weakness and/or pale skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea


• loss of appetite


• muscle weakness


• nausea or vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Quinidex Extentabs side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Quinidex Extentabs resources

• Quinidex Extentabs Side Effects (in more detail)
• Quinidex Extentabs Use in Pregnancy & Breastfeeding
• Drug Images
• Quinidex Extentabs Drug Interactions
• Quinidex Extentabs Support Group
• 0 Reviews for Quinidex Extentabs - Add your own review/rating

• Quinidex Extentabs Concise Consumer Information (Cerner Multum)


• Quin-G Concise Consumer Information (Cerner Multum)


• Quinidine Professional Patient Advice (Wolters Kluwer)


• Quinidine Prescribing Information (FDA)


• Quinidine Gluconate Monograph (AHFS DI)

Compare Quinidex Extentabs with other medications

• Arrhythmia
• Malaria

Aralen

Generic Name: Chloroquine (KLOR-oh-kwin)
Brand Name: Aralen

Aralen is used for:

Treating and suppressing acute attacks of certain strains of malaria and a certain type of parasitic infection (extraintestinal amebiasis). It may also be used for other conditions as determined by your doctor.

Aralen is an aminoquinoline. It is thought to kill sensitive malaria parasites by stopping normal metabolism inside the parasite.

Do NOT use Aralen if:

• you are allergic to any ingredient in Aralen


• you have vision problems or retinal changes


• you are taking arsenic, astemizole, terfenadine, cimetidine, cisapride, quinacrine, or dofetilide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aralen:

Some medical conditions may interact with Aralen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines or other substances


• if you have porphyria or any other blood disease, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, or a history of seizures


• if you have psoriasis, stomach or intestinal problems, liver disease, or central nervous system problems

Some MEDICINES MAY INTERACT with Aralen. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Cimetidine or quinacrine because the side effects of Aralen may be increased


• Ampicillin, rabies vaccine, or thyroid hormones (eg, levothyroxine) because the effectiveness of these medicines may be decreased


• Arsenic, astemizole, cisapride, dofetilide, or terfenadine because the risk of severe side effects, including irregular heartbeat, may be increased


• Cyclosporine because its side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aralen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aralen:

Use Aralen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Aralen is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Aralen at home, carefully follow the injection procedures taught to you by your health care provider.


• If Aralen contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.


• If you miss a dose of Aralen, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Aralen.

Important safety information:

• Aralen may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Aralen. Using Aralen alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Aralen may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Aralen. Use a sunscreen or protective clothing if you must be outside for a prolonged period.


• Contact your health care provider if you notice any muscle weakness or problems with vision or hearing. Your knee and ankle reflexes will be tested periodically.


• LAB TESTS, such as complete blood cell counts and eye tests, may be needed to monitor your progress. Be sure to keep appointments.


• Use Aralen with caution in the ELDERLY because they may be more sensitive to its effects.


• Caution is advised when using Aralen in CHILDREN because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Aralen, discuss with your doctor the benefits and risks of using Aralen during pregnancy. Aralen is excreted in breast milk. Do not breast-feed while taking Aralen.

Possible side effects of Aralen:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; clumsiness; diarrhea; dizziness; feeling of whirling motion; mild headache; nausea; stomach cramps; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; change in color or skin or inside of mouth; diarrhea; difficulty seeing and reading (words, letters, or parts of objects missing when reading); fever or sore throat; hair loss; hearing loss; mood changes; ringing in the ears; seizures; sensitivity to sunlight; unusual bleeding or bruising; unusual weakness; vision problems; weight loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Aralen side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; drowsiness; excessive excitability; fainting; headache; irregular heartbeat; loss of consciousness; mood changes; seizures; severe drowsiness or dizziness; slow, shallow breathing.

Proper storage of Aralen:

Store Aralen in a tightly closed container at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aralen out of the reach of children and away from pets.

General information:

• If you have any questions about Aralen, please talk with your doctor, pharmacist, or other health care provider.


• Aralen is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aralen. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Aralen resources

• Aralen Side Effects (in more detail)
• Aralen Use in Pregnancy & Breastfeeding
• Aralen Drug Interactions
• Aralen Support Group
• 0 Reviews for Aralen - Add your own review/rating

Compare Aralen with other medications

• Amebiasis
• Malaria
• Malaria Prevention
• Sarcoidosis

Guaifenesin/Codeine

Pronunciation: gwye-FEN-e-sin/KOE-deen
Generic Name: Guaifenesin/Codeine
Brand Name: Examples include Brontex and Pro-Clear

Guaifenesin/Codeine is used for:

Relieving cough and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Guaifenesin/Codeine is a cough suppressant and expectorant combination. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough. The expectorant works by loosening mucus and lung secretions in the chest and making coughs more productive.

Do NOT use Guaifenesin/Codeine if:

• you are allergic to any ingredient in Guaifenesin/Codeine or any other codeine- or morphine-related medicine (eg, oxycodone)


• you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)


• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Guaifenesin/Codeine:

Some medical conditions may interact with Guaifenesin/Codeine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to morphine, codeine, or any other opiate (eg, hydrocodone, dihydrocodeine, oxycodone)


• if you have a history of an enlarged prostate gland or other prostate problems, heart problems, kidney or liver problems, a blockage of your bowel or bladder, adrenal gland problems (eg, Addison disease), or an underactive thyroid


• if you have a history of stomach problems, bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent abdominal surgery


• if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus


• if you have recently had any head injury, brain injury or tumor, increased pressure in the brain, infection of the brain or nervous system, epilepsy, or seizures


• if you have a history of alcohol abuse, drug abuse, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Guaifenesin/Codeine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• HIV protease inhibitors (eg, ritonavir) because the risk of side effects from Guaifenesin/Codeine may be increased


• Cimetidine, digoxin, droxidopa, or sodium oxybate (GHB) because the risk of severe drowsiness, breathing problems, seizures, irregular heartbeat, or heart attack may be increased


• Naltrexone or quinidine because the effectiveness of Guaifenesin/Codeine may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Guaifenesin/Codeine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Guaifenesin/Codeine:

Use Guaifenesin/Codeine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Guaifenesin/Codeine by mouth with or without food.


• Drink plenty of water while taking Guaifenesin/Codeine.


• If you miss a dose of Guaifenesin/Codeine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Guaifenesin/Codeine.

Important safety information:

• Guaifenesin/Codeine may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Guaifenesin/Codeine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.


• Guaifenesin/Codeine may interfere with certain lab test results. Make sure that your doctor and lab personnel know that you are taking Guaifenesin/Codeine.


• Tell your doctor or dentist that you take Guaifenesin/Codeine before you receive any medical or dental care, emergency care, or surgery.


• Use Guaifenesin/Codeine with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Guaifenesin/Codeine in CHILDREN; they may be more sensitive to its effects.


• Guaifenesin/Codeine should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Guaifenesin/Codeine while you are pregnant. It is not known if Guaifenesin/Codeine is found in breast milk. Do not breast-feed while taking Guaifenesin/Codeine.

Possible side effects of Guaifenesin/Codeine:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Guaifenesin/Codeine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Guaifenesin/Codeine:

Store Guaifenesin/Codeine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guaifenesin/Codeine out of the reach of children and away from pets.

General information:

• If you have any questions about Guaifenesin/Codeine, please talk with your doctor, pharmacist, or other health care provider.


• Guaifenesin/Codeine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Guaifenesin/Codeine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Guaifenesin/Codeine resources

• Guaifenesin/Codeine Side Effects (in more detail)
• Guaifenesin/Codeine Dosage
• Guaifenesin/Codeine Use in Pregnancy & Breastfeeding
• Drug Images
• Guaifenesin/Codeine Drug Interactions
• Guaifenesin/Codeine Support Group
• 21 Reviews for Guaifenesin/Codeine - Add your own review/rating

Compare Guaifenesin/Codeine with other medications

• Cough

Phenergan Suppositories

Pronunciation: proe-METH-a-zeen
Generic Name: Promethazine
Brand Name: Phenergan

Phenergan Suppositories should not be used in children younger than 2 years old. Potentially fatal side effects (eg, difficult or slowed breathing, drowsiness leading to coma) may occur in this age group when taking Phenergan Suppositories.

Caution should be used when using Phenergan Suppositories in children 2 years old and older. The lowest possible dose should be used in this age group, and Phenergan Suppositories should not be used with other medicines that cause slowed breathing.

Phenergan Suppositories are used for:

Relieving allergy symptoms, including hives or runny nose. It is used to prevent and control nausea and vomiting during and after surgery. It is also used to help produce light sleep; prevent and treat motion sickness; or treat pain after surgery, in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Phenergan Suppositories are a phenothiazine. It works by blocking the action of various chemicals in the brain, preventing or reducing the symptoms these chemicals cause.

Do NOT use Phenergan Suppositories if:

• you are allergic to any ingredient in Phenergan Suppositories


• you have severe central nervous system depression or are in a coma


• you are taking astemizole, cisapride, terfenadine, or tramadol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Phenergan Suppositories:

Some medical conditions may interact with Phenergan Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have nervous system problems, bone marrow depression, alcoholism, heart problems, a blood disease, glaucoma, increased eye pressure, low blood pressure, liver problems, prostate problems, Parkinson disease, seizures, or Reye syndrome, or if you have been in a coma

Some MEDICINES MAY INTERACT with Phenergan Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Charcoal or lithium because they may decrease Phenergan Suppositories's effectiveness


• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), astemizole, cisapride, general anesthetics (eg, thiopental), methyldopa, terfenadine, or tramadol because side effects, such as low blood pressure and seizures, may occur


• ACE inhibitors (eg, enalapril), haloperidol, lithium, meperidine, metrizamide, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), naltrexone, polypeptide antibiotics (eg, actinomycin), or trazodone because the risk of their side effects may be increased by Phenergan Suppositories


• Bromocriptine, epinephrine, levodopa, or pergolide because their effectiveness may be decreased by Phenergan Suppositories

This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenergan Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Phenergan Suppositories:

Use Phenergan Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wash your hands before and after using Phenergan Suppositories. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it. Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.


• If you are using Phenergan Suppositories for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.


• If you miss a dose of Phenergan Suppositories and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Phenergan Suppositories.

Important safety information:

• Phenergan Suppositories may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Phenergan Suppositories with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Phenergan Suppositories; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Phenergan Suppositories. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.


• Phenergan Suppositories may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Phenergan Suppositories. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Use Phenergan Suppositories with extreme caution in the ELDERLY; they may be more sensitive to its effects.


• Phenergan Suppositories should not be used in CHILDREN younger than 2 years old. Serious, and sometimes fatal, side effects (difficult or slowed breathing, drowsiness leading to coma) have occurred when Phenergan Suppositories has been used in children in this age group.


• Phenergan Suppositories should be used with extreme caution in CHILDREN 2 years old or older. The lowest effective dose should be used in children 2 years old and older.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Phenergan Suppositories while you are pregnant. If you are or will be breast-feeding while you use Phenergan Suppositories, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Phenergan Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; dry mouth; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; excessive sweating; fainting; fever, chills, or sore throat; hallucinations; mental or mood changes (eg, agitation, delirium, exaggerated sense of well-being, excitability, hysteria, nervousness); seizures; severe of persistent dizziness; shortness of breath or trouble breathing; slow or fast heartbeat; tremor; trouble sleeping; uncontrolled muscle movements; unusual brusing or bleeding; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Phenergan side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include convulsions; dry mouth; flushing; hallucinations; loss of consciousness; nightmares; seizures; shortness of breath; trouble breathing; unusual drowsiness or restlessness.

Proper storage of Phenergan Suppositories:

Store Phenergan Suppositories in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep Phenergan Suppositories out of the reach of children and away from pets.

General information:

• If you have any questions about Phenergan Suppositories, please talk with your doctor, pharmacist, or other health care provider.


• Phenergan Suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Phenergan Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Phenergan resources

• Phenergan Side Effects (in more detail)
• Phenergan Use in Pregnancy & Breastfeeding
• Drug Images
• Phenergan Drug Interactions
• Phenergan Support Group
• 45 Reviews for Phenergan - Add your own review/rating

Compare Phenergan with other medications

• Allergic Reactions
• Anaphylaxis
• Hay Fever
• Light Sedation
• Motion Sickness
• Nausea/Vomiting
• Opiate Adjunct
• Sedation
• Urticaria
• Vertigo