Premenopausal Anovulation Medications

There are currently no drugs listed for "Premenopausal Anovulation".

Learn more about Premenopausal Anovulation

Micromedex Care Notes:

• Female Infertility

Medical Encyclopedia:

• Infertility

Drug List:

Propranolol NEGPF

Propranolol NEGPF may be available in the countries listed below.

Ingredient matches for Propranolol NEGPF

Propranolol

Propranolol hydrochloride (a derivative of Propranolol) is reported as an ingredient of Propranolol NEGPF in the following countries:

• China

International Drug Name Search

Bromazepam

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

N05BA08

CAS registry number (Chemical Abstracts Service)

0001812-30-2

Chemical Formula

C14-H10-Br-N3-O

Molecular Weight

316

Therapeutic Categories

Anxiolytic agent

Benzodiazepine derivative

Hypnotic agent

Chemical Name

2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-

Foreign Names

• Bromazepamum (Latin)
• Bromazepam (German)
• Bromazépam (French)
• Bromazepam (Spanish)

Generic Names

• Bromazepam (OS: BAN, DCIT, USAN, JAN)
• Bromazépam (OS: DCF)
• Ro 5-3350 (IS: Roche)
• Bromazepam (PH: BP 2010, JP XV, Ph. Eur. 6)
• Bromazépam (PH: Ph. Eur. 6)
• Bromazepamum (PH: Ph. Eur. 6)

Brand Names

• Akamon
  Medochemie, Cyprus; Medochemie, Hong Kong; Medochemie, Iraq; Medochemie, Jordan; Medochemie, Malta; Medochemie, Sudan; Medochemie, Taiwan; Medochemie, Yemen



• Anconevron
  Farmanic Chemipharma, Greece



• Ansiosel
  Psipharma, Colombia



• Ansium
  Bristol-Myers Squibb, Peru



• Anxiocalm
  Socobom, Luxembourg



• Anxiomyl
  ADWYA, Tunisia



• Anxopam
  Popular, Bangladesh



• Anxyrex
  Sanofi-Aventis, France



• Apo-Bromazepam
  Apotex, Canada; Apotex, Guyana



• Atemperator
  Ivax, Argentina



• Benedorm
  Ariston, Argentina



• Benzepam
  Benham, Bangladesh



• Bopam
  Opsonin, Bangladesh



• Brazepam
  Aspen Pharmacare, South Africa



• Brixopan
  Epifarma, Italy



• Bromalex
  Vitoria, Portugal



• Bromam
  Sandoz, Denmark



• Bromased
  SM Pharma, Venezuela



• Bromatop
  Apotex, Belgium



• Bromazanil
  Hexal, Germany; Hexal, Luxembourg



• Bromaze
  Hexal, South Africa



• Bromazep
  Orion, Bangladesh



• Bromazepam A
  Apothecon, Netherlands



• Bromazepam ABC
  ABC, Italy



• Bromazepam Actavis
  Actavis, Italy; Actavis, Netherlands



• Bromazepam AL
  Aliud, Germany



• Bromazepam Almus
  Almus, Italy



• Bromazepam Alter
  Alter, Italy



• Bromazépam Arrow
  Arrow, France



• Bromazepam beta
  Betapharm, Germany



• Bromazepam Billix
  Billix Pharma, Germany



• Bromazépam Biogaran
  Biogaran, France



• Bromazepam Calox
  Calox, Venezuela



• Bromazepam CF
  Centrafarm, Netherlands



• Bromazépam CristerS
  CristerS, France



• Bromazepam DOC
  DOC Generici, Italy



• Bromazepam dura
  Mylan dura, Germany



• Bromazepam EG
  EG, Italy; Eurogenerics, Belgium



• Bromazépam EG
  EG Labo, France



• Bromazepam Genericon
  Genericon, Austria



• Bromazepam Generis
  Generis, Portugal



• Bromazepam Germed
  Pliva, Italy



• Bromazepam GMP
  Giempi, Venezuela



• Bromazepam Heumann
  Heumann, Germany



• Bromazepam Hexal
  Hexal, Italy



• Bromazépam Isomed
  Ratiopharm, France



• Bromazepam Kela
  Kela, Belgium



• Bromazepam L.CH.
  Chile, Chile



• Bromazepam La Santé
  La Santé, Colombia



• Bromazepam Lannacher
  Lannacher, Estonia; Lannacher, Lithuania; Lannacher, Latvia



• Bromazepam LPH
  Labormed Pharma, Romania



• Bromazepam Merck
  Merck, Colombia



• Bromazépam Merck
  Merck Génériques, Tunisia



• Bromazepam MK
  Bonima, Costa Rica; Bonima, Dominican Republic; Bonima, Guatemala; Bonima, Honduras; Bonima, Nicaragua; Bonima, Panama; Bonima, El Salvador



• Bromazepam Mylan
  Mylan, Italy



• Bromazépam Mylan
  Mylan, France



• Bromazepam PCH
  Pharmachemie, Netherlands



• Bromazépam Qualimed
  Qualimed, France



• Bromazepam Ranbaxy
  Ranbaxy, Italy



• Bromazepam ratiopharm
  Ratiopharm, Germany; Ratiopharm, Italy; ratiopharm, Netherlands



• Bromazépam Ratiopharm
  Ratiopharm, France



• Bromazépam RPG
  RPG, France



• Bromazepam Sandoz
  Sandoz, Belgium; Sandoz, Italy; Sandoz, Netherlands



• Bromazépam Sandoz
  Sandoz, France



• Bromazepam Sigma Tau
  Sigma Tau, Italy



• Bromazepam Temis
  Temis-Lostalo, Argentina



• Bromazepam Teva
  Teva, Belgium; Teva, Italy



• Bromazépam Teva
  Teva Santé, France



• Bromazepam Vannier
  Vannier, Argentina



• Bromazepam Winthrop
  Winthrop, Italy



• Bromazépam Winthrop
  Sanofi-Aventis, France



• Bromazépam Zydus
  Zydus, France



• Bromazepam
  Farmindustria, Peru; Genéricos Venezolanos, Venezuela; Hersil, Peru; Induquimica, Peru; Infarmasa, Peru; Kimiceg, Venezuela; Marfan, Peru; Meyer, Venezuela; Mintlab, Chile; Perugen, Peru; Slavia Pharm, Romania; Spefar, Venezuela; Terapia, Romania; Zorka, Serbia



• Bromazepam-1A Pharma
  1A Pharma, Germany



• Bromazepam-Eurogenerics
  Eurogenerics, Luxembourg



• Bromazepam-neuraxpharm
  Neuraxpharm, Germany



• Bromazepam-Tchaikapharma
  Tchaikapharma, Bulgaria



• Bromazep-CT
  CT Arzneimittel, Germany



• Bromidem
  Nycomed, Belgium; Sandipro, Luxembourg



• Brominter
  Cheminter, Guatemala



• Bronium
  Doctor's Chemical Work, Bangladesh



• Calmepam
  GlaxoSmithKline, Romania



• Compendium
  Polifarma, Italy



• Creosedin
  Rontag, Argentina



• Dipax
  Markos, Peru



• Docbromaze
  Docpharma, Belgium



• Equisedin
  Lazar, Argentina



• Estomina
  Fabra, Argentina



• Evagelin
  Help, Greece



• Fabozepam
  Fabop, Argentina



• Fada Bromazepam
  Fada, Argentina



• Finaten
  Microsules, Argentina



• Gasmol
  Richmond, Argentina



• Gen-Bromazepam
  Genpharm, Canada



• Gityl
  Krewel, Germany



• Laxonil
  Rephco, Bangladesh



• Laxotan
  Chugai, Japan



• Laxyl
  Square, Bangladesh



• Lectopam
  Roche, Canada



• Lekotam
  Lek, Bosnia & Herzegowina; Lek, Croatia (Hrvatska); Lek, Slovenia



• Lenitin
  Teva, Israel



• Lexatin
  Roche, Spain



• Lexaurin
  Krka, Bosnia & Herzegowina; Krka, Czech Republic; Krka, Croatia (Hrvatska); Krka, Serbia; Krka, Slovenia; Krka, Slovakia



• Lexil (Bromazepam and Propanteline)
  Teofarma, Italy



• Lexilium
  Alkaloid, Bosnia & Herzegowina; Alkaloid, Croatia (Hrvatska); Alkaloid, Serbia; Alkaloid, Slovenia; Remedica, Cyprus; Remedica, Kenya; Remedica, Malta; Remedica, Sudan; Remedica, Zimbabwe



• Lexnil
  Asiatic Lab, Bangladesh



• Lexomil
  Roche, France; Teriak, Tunisia



• Lexopam
  United Pharmaceutical, United Arab Emirates; United Pharmaceutical, Bahrain; United Pharmaceutical, Iraq; United Pharmaceutical, Jordan; United Pharmaceutical, Libya; United Pharmaceutical, Qatar; United Pharmaceutical, Saudi Arabia; United Pharmaceutical, Sudan; United Pharmaceutical, Yemen



• Lexostad
  Stada, Germany



• Lexotan
  Actavis, Georgia; Pharmacia, Bulgaria; Roche, United Arab Emirates; Roche, Argentina; Roche, Australia; Roche, Aruba; Roche, Belgium; Roche, Bahrain; Roche, Benin; Roche, Bolivia; Roche, Brazil; Roche, Botswana; Roche, Congo; Roche, Cote D'ivoire; Roche, Chile; Roche, Cameroon; Roche, Colombia; Roche, Cyprus; Roche, Denmark; Roche, Ecuador; Roche, Gabon; Roche, Georgia; Roche, Ghana; Roche, Guinea; Roche, Greece; Roche, Hong Kong; Roche, Hong Kong; Roche, Indonesia; Roche, Ireland; Roche, Iceland; Roche, Italy; Roche, Jamaica; Roche, Jordan; Roche, Kenya; Roche, Cambodia; Roche, Kuwait; Roche, Laos; Roche, Sri Lanka; Roche, Lithuania; Roche, Luxembourg; Roche, Morocco; Roche, Moldova; Roche, Mali; Roche, Malta; Roche, Mauritius; Roche, Malawi; Roche, Mexico; Roche, Malaysia; Roche, Namibia; Roche, Nigeria; Roche, Oman; Roche, Peru; Roche, Philippines; Roche, Pakistan; Roche, Poland; Roche, Portugal; Roche, Paraguay; Roche, Qatar; Roche, Romania; Roche, Russian Federation; Roche, Saudi Arabia; Roche, Sudan; Roche, Singapore; Roche, Togo; Roche, Thailand; Roche, Trinidad & Tobago; Roche, Taiwan; Roche, Tanzania; Roche, Uganda; Roche, Uruguay; Roche, Vietnam; Roche, South Africa; Roche, Zambia; Roche, Zaire; Roche, Zimbabwe; Roche Pharmaceutical, Japan; Roche RX, Singapore



• Lexotanil Roche
  Roche, Austria



• Lexotanil
  Roche, Argentina; Roche, Bangladesh; Roche, Bahrain; Roche, Switzerland; Roche, Chile; Roche, Czech Republic; Roche, Germany; Roche, Estonia; Roche, Ethiopia; Roche, Georgia; Roche, Greece; Roche, Sri Lanka; Roche, Lithuania; Roche, Latvia; Roche, Oman; Roche, Romania; Roche, Venezuela



• Libronil
  Coup, Greece



• Neo OPT
  Optimed, Germany



• Nervan
  Meyer, Venezuela



• Neural
  Gross, Brazil



• Neurilan
  Gross, Brazil



• Neurozepam
  Sandoz, Argentina



• Nightus
  Beximco, Bangladesh



• Normoc
  Merckle Recordati, Germany



• Notens
  Aristopharma, Bangladesh



• Notorium
  Adelco, Greece; Adelco, Malta



• Novepam
  Ram Pharmaceutical, Oman



• Nulastres
  Duncan, Argentina



• Octanyl
  Bagó, Argentina; Bagó, Colombia; Bagó, Costa Rica; Bagó, Dominican Republic; Bagó, Honduras; Bagó, Panama; Bagó, El Salvador



• Otedram
  Psicofarma, Mexico



• Pascalium
  Pharmathen, Greece



• Pymeroxomil
  PMP, Vietnam



• Quiétiline
  Sciencex, France



• Restol
  Eskayef, Bangladesh



• Sandoz Bromazepam
  Sandoz, South Africa



• Sandoz Captopril
  Sandoz, South Africa



• Sedam
  Sandoz, Poland



• Seniran
  Sandoz, Japan



• Serene
  Renata, Bangladesh



• Serenit
  Dollder, Venezuela



• Siesta
  Incepta, Bangladesh



• Sipcar
  Laboratorios, Argentina



• Somalium
  Aché, Brazil



• Tenapam
  General Pharma, Bangladesh



• Tenil
  Acme, Bangladesh



• Totasedan
  Roemmers, Peru



• Transomil
  Saidal, Algeria



• Tritopan
  Klonal, Argentina



• Ultramidol
  Winthrop, Portugal



• Xionil
  Novartis, Bangladesh



• Zepam
  ACI, Bangladesh

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Biodacyna

Biodacyna may be available in the countries listed below.

Ingredient matches for Biodacyna

Amikacin

Amikacin is reported as an ingredient of Biodacyna in the following countries:

• Vietnam

Amikacin sulfate (a derivative of Amikacin) is reported as an ingredient of Biodacyna in the following countries:

• Lithuania


• Poland

International Drug Name Search

Isosorbide dinitraat Fagron

Isosorbide dinitraat Fagron may be available in the countries listed below.

Ingredient matches for Isosorbide dinitraat Fagron

Isosorbide Dinitrate

Isosorbide Dinitrate is reported as an ingredient of Isosorbide dinitraat Fagron in the following countries:

• Netherlands

International Drug Name Search

Dapsone topical

Class: Skin and Mucous Membrane Agents, Miscellaneous
ATC Class: D10AX05
Chemical Name: Diaminodiphenylsulfone
Molecular Formula: C₁₂H₁₂N₂O₂S
CAS Number: 80-08-0
Brands: Aczone

Introduction

Synthetic sulfone^{1 2 3 5 18} with anti-infective and anti-inflammatory effects.^{2 3 5 18}

Uses for Dapsone

Acne Vulgaris

Topical treatment of acne vulgaris.^{1 2 3 4 11}

Effective against inflammatory acne lesions and, to a lesser extent, noninflammatory acne lesions.^{2 3}

Dapsone Dosage and Administration

Administration

Topical Administration

Administer topically to the skin as a 5% gel.¹

For external use only.¹ Do not use orally or intravaginally; avoid contact with the mouth and eyes.¹

Gently cleanse and dry the acne-affected area prior to application.¹ Apply a pea-sized amount of dapsone 5% gel in a thin layer; rub in gently and completely.¹

The gel is gritty with visible drug substance particles.¹ Wash hands after applying the gel.¹

Dosage

Pediatric Patients

Acne Vulgaris

Topical

Children ≥12 years of age: Apply a thin layer of dapsone 5% gel to cleansed affected area twice daily.¹

Reassess use of the drug if improvement does not occur after 12 weeks of treatment.¹

Has been used for up to 12 months in clinical studies.³

Adults

Acne Vulgaris

Topical

Apply a thin layer of dapsone 5% gel to the cleansed affected area twice daily.¹

Reassess use of the drug if improvement does not occur after 12 weeks of treatment.¹

Has been used for up to 12 months in clinical studies.³

Cautions for Dapsone

Contraindications

• 
  

  Manufacturer states none known.¹

  
  

Warnings/Precautions

Sensitivity Reactions

Moderate erythema has been reported when topical dapsone 5% gel was evaluated in combined contact sensitization/irritation studies.¹ Pruritus,^{2 3 6} rash,³ and contact dermatitis⁶ were reported in some patients receiving the topical gel for treatment of acne vulgaris.

Oral dapsone has been associated with hypersensitivity reactions that include severe dermatologic reactions.^{1 7 16} (See Dermatologic Reactions under Cautions.) Hypersensitivity reactions reported with oral dapsone have also included fever, malaise, hepatitis, and hemolysis.¹⁰

Topical dapsone did not induce phototoxicity or photoallergy in human dermal safety studies.¹

Hematologic Effects

Oral dapsone has been associated with dose-related hemolysis and hemolytic anemia.^{1 14} Agranulocytosis also reported in patients receiving oral dapsone.^{1 9} Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more prone to hemolysis when receiving certain drugs.¹ G6PD deficiency is most prevalent in populations of African, South Asian, Middle Eastern, and Mediterranean ancestry.¹

There were no reports of clinically relevant hemolysis or hemolytic anemia in clinical studies evaluating topical dapsone 5% gel in individuals with acne vulgaris, including individuals with G6PD deficiency.^{1 2 3 6} However, laboratory changes suggestive of hemolysis (slight decreases in hemoglobin) occurred in some individuals with G6PD deficiency using the topical gel.^{1 2 6}

If signs and symptoms suggestive of hemolytic anemia occur, discontinue topical dapsone therapy.¹

Because of the potential for hemolytic reactions, do not use topical dapsone 5% gel in individuals receiving oral dapsone or antimalarial agents.¹ (See Specific Drugs under Interactions.)

Concomitant use of topical dapsone 5% gel and co-trimoxazole may increase the risk of hemolysis in patients with G6PD deficiency.¹ (See Specific Drugs under Interactions.)

Peripheral Neuropathy

Oral dapsone has been associated with peripheral neuropathy (motor loss and muscle weakness).¹

Peripheral neuropathy was not reported in clinical studies evaluating topical dapsone 5% gel for the treatment of acne vulgaris.¹

Dermatologic Reactions

Oral dapsone has been associated with serious skin reactions, including toxic epidermal necrolysis, erythema multiforme, morbilliform and scarlatiniform reactions, bullous and exfoliative dermatitis, erythema nodosum, and urticaria.^{1 7}

Although erythema,¹ pruritus,^{2 3} and rash³ were reported in clinical studies evaluating topical dapsone 5% gel for the treatment of acne vulgaris, more severe dermatologic reactions were not reported.¹

Specific Populations

Pregnancy

Category C.¹

Oral dapsone has been associated with embryocidal effects in rats and rabbits when used in dosages approximately 800 and 500 times, respectively, the systemic exposure (based on AUC) observed in human females receiving the maximum recommended dosage of topical dapsone 5% gel.¹ These effects were probably secondary to maternal toxicity.¹

Use during pregnancy only if potential benefits outweigh potential risks to the fetus.¹

Lactation

Distributed into milk following oral administration.¹ Systemic absorption is low following topical application of dapsone 5% gel; however, because of the potential to cause adverse reactions in nursing infants, discontinue nursing or discontinue topical dapsone therapy.¹

Pediatric Use

Safety and efficacy not established in children <12 years of age.¹

Geriatric Use

Insufficient experience with topical dapsone 5% gel in geriatric patients ≥65 years of age to determine whether such individuals respond differently than younger individuals.¹

Common Adverse Effects

Local reactions at the application site (oiliness/peeling, dryness, erythema).^{1 2}

Interactions for Dapsone

Although only small amounts of dapsone are absorbed systemically following topical application to skin, the possibility that drug interactions could occur should be considered.¹ Concomitant use of oral dapsone and certain drugs (e.g., rifampin, anticonvulsants, St. John's wort) may increase the formation of dapsone hydroxylamine, a dapsone metabolite associated with hemolysis.¹ In addition, concomitant use of oral dapsone and folic acid antagonists (e.g., pyrimethamine) may increase the likelihood of adverse hematologic effects.¹

Specific Drugs

Drug	Interaction	Comments
Antimalarial agents	Increased risk of hemolytic reactions if topical dapsone used concomitantly with antimalarial agents1	Do not use topical dapsone in patients receiving antimalarial agents1
Benzoyl peroxide	In vitro, combinations of topical dapsone 5% gel and topical benzoyl peroxide resulted in an orange discoloration17 Concomitant use of topical dapsone 5% gel and topical benzoyl peroxide in individuals with acne vulgaris may result in temporary local yellow or orange discoloration of the skin and facial hair;1 usually resolves in 4–57 days1
Co-trimoxazole	Concomitant use of topical dapsone 5% gel and oral co-trimoxazole results in increased systemic exposure to dapsone and dapsone metabolites; pharmacokinetics of co-trimoxazole not affected1 5 Possible increased risk of hemolysis in patients with G6PD deficiency1
Dapsone, oral	Increased risk of hemolytic reactions if oral and topical dapsone used concomitantly1	Do not use topical dapsone in patients receiving oral dapsone1

Dapsone Pharmacokinetics

Absorption

Bioavailability

Absorbed systemically following topical application to skin.^{1 5}

In patients with acne vulgaris skin lesions, plasma concentrations of dapsone are detectable within 2 hours after the first dose of topical dapsone 5% gel.⁵

After topical application of dapsone 5% gel to acne vulgaris skin lesions on the face, upper back, shoulders, and/or upper chest (up to approximately 22.5% of total body surface area) twice daily for 14 days, mean peak plasma concentrations of the drug were 19.4 ng/mL and the median time to peak concentrations after a dose was 9 hours.⁵

In a long-term safety study of dapsone 5% gel, there was no evidence that systemic exposure increases over time.¹

Systemic exposure (AUC) following a 14-day regimen of dapsone 5% gel is 126 times lower than systemic exposure (AUC) following a single 100-mg dose of oral dapsone.⁵

Special Populations

Systemic dapsone exposure following topical application of dapsone 5% gel in children 12–15 years of age is similar to that reported in those ≥16 years of age.¹

Stability

Storage

Topical

Gel

20–25°C (may be exposed to 15–30°C).¹ Do not freeze.¹

ActionsActions

• 
  

  Synthetic sulfone^{1 2 3 5 18} with anti-infective and anti-inflammatory effects.^{3 5 18}

  
  


• 
  

  For dermatologic use, dapsone is commercially available in an aqueous gel base.¹

  
  


• 
  

  Mechanism of action in the treatment of acne vulgaris not known, but may result from a combination of both anti-inflammatory and anti-infective effects.^{1 2 3 18}

  
  


• 
  

  Dapsone exerts a variety of anti-inflammatory effects.^{2 3 18} The drug may inhibit myeloperoxidase- and hydrogen peroxide-based cytotoxic systems in neutrophils or may act as a scavenger of reactive oxygen species, thereby minimizing inflammation associated with generation of these reactive species.¹⁸

  
  


• 
  

  The anti-infective effects of dapsone involve inhibition of folic acid synthesis in susceptible organisms.¹⁸

  
  


• 
  

  In vitro, dapsone has some antibacterial activity against Propionibacterium acnes.¹⁸ It is not known whether topical dapsone therapy results in decreased susceptibility of P. acnes to other drugs used to treat acne.¹

  
  

Advice to Patients

• 
  

  Importance of using as directed by the clinician and only for condition prescribed.¹

  
  


• 
  

  Advise patient that topical dapsone is for external use only and should not be used orally or intravaginally; importance of avoiding contact with the mouth and eyes.¹

  
  


• 
  

  Importance of storing at room temperature and protecting the drug from freezing.¹

  
  


• 
  

  Importance of informing clinician of glucose-6-phosphate dehydrogenase (G6PD) deficiency.¹

  
  


• 
  

  Importance of reporting any signs of adverse reactions to a clinician.¹

  
  


• 
  

  Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs, especially topical agents applied to the skin (e.g., preparations containing benzoyl peroxide).¹

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹

  
  


• 
  

  Importance of informing patients of other important precautionary information.¹ (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Dapsone

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Topical	Gel	5%	Aczone	Allergan

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions July 2010. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. Allergan. Aczone (dapsone) gel 5% prescribing information. Irvine, CA. 2009 Mar.

2. Draelos ZD, Carter E, Maloney JM et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007; 56:439.e1-10.

3. Lucky AW, Maloney JM, Roberts J et al. Dapsone gel 5% for the treatment of acne vulgaris: safety and efficacy of long-term (1 year) treatment. J Drugs Dermatol. 2007; 6:981-7. [PubMed 17966175]

4. Raimer S, Maloney JM, Bourcier M et al. Efficacy and safety of dapsone gel 5% for the treatment of acne vulgaris in adolescents. Cutis. 2008; 81:171-8. [PubMed 18441772]

5. Thiboutot DM, Willmer J, Sharata H et al. Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris. Clin Pharmacokinet. 2007; 46:697-712. [PubMed 17655376]

6. Piette WW, Taylor S, Pariser D et al. Hematologic safety of dapsone gel, 5%, for topical treatment of acne vulgaris. Arch Dermatol. 2008; 144:1564-70. [PubMed 19075138]

7. Agrawal S, Agarwalla A. Dapsone hypersensitivity syndrome: a clinico-epidemiological review. J Dermatol. 2005; 32:883-9. [PubMed 16361748]

9. Coleman MD. Dapsone-mediated agranulocytosis: risks, possible mechanisms and prevention. Toxicology. 2001; 162:53-60. [PubMed 11311458]

10. Corp CC, Ghishan FK. The sulfone syndrome complicated by pancreatitis and pleural effusion in an adolescent receiving dapsone for treatment of acne vulgaris. J Pediatr Gastroenterol Nutr. 1998; 26:103-5. [PubMed 9443128]

11. Del Rosso JQ. Newer topical therapies for the treatment of acne vulgaris. Cutis. 2007; 80:400-10. [PubMed 18189027]

14. Ismail R. Acne fulminans with dapsone induced haemolysis: a case report. Med J Malaysia. 1987; 42:124-6. [PubMed 2971861]

16. Tomecki KJ, Catalano CJ. Dapsone hypersensitivity. The sulfone syndrome revisited. Arch Dermatol. 1981; 117:38-9. [PubMed 6450569]

17. Dubina MI, Fleischer AB. Interaction of topical sulfacetamide and topical dapsone with benzoyl peroxide. Arch Dermatol. 2009; 145:1027-9. [PubMed 19770443]

18. Center for Drug Evaluation and Research. Microbiology review of NDA application 21-794. 2005 Jun 20.

More Dapsone topical resources

• Dapsone topical Dosage
• Dapsone topical Use in Pregnancy & Breastfeeding
• Dapsone topical Drug Interactions
• Dapsone topical Support Group
• 35 Reviews for Dapsone - Add your own review/rating

• Aczone Prescribing Information (FDA)


• Aczone Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Aczone Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Aczone Consumer Overview

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Isosorbide Mononitrate is reported as an ingredient of Mononitrato de Isossorbido Merck in the following countries:

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